Product Name :
iNOS Recombinant Rabbit Monoclonal Antibody [JE59-61]
Predicted band size :
131 kDa
Observed band size :
131 kDa
Synonyms:
HEP-NOS antibody Hepatocyte NOS antibody HEPNOS antibody inducible antibody Inducible nitric oxide synthase antibody Inducible NO synthase antibody Inducible NOS antibody iNOS antibody MAC NOS antibody Macrophage NOS antibody 展开
Function :
Nitric oxide synthase, inducible is an enzyme which is encoded by the NOS2 gene in humans and mice. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms. Nitric oxide synthase is expressed in epithelial cells of the liver, lung and bone marrow. It is inducible by a combination of lipopolysaccharide and certain cytokines. Nitric oxide is a reactive free radical mediating in neurotransmission, antimicrobial and antitumoral activities. In mice, the function of Nos2 in immunity against a number of viruses, bacteria, fungi, and parasites has been well characterized, whereas in humans the role of NOS2 has remained elusive and controversial. Nos2 is important for protective immunity against CMV. Caveolin 1 has been shown to interact with Nitric oxide synthase 2A. and Rac2.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within Human iNOS aa 1-300 / 1,153.
Species reactivity:
Human, Mouse
Verify application:
WB, IF-Cell
Coupling :
unconjugated
Clone number:
JE59-61
RRID:
AB_3072696
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.4-(Tert-butyl)picolinic acid site Aliquot store at -20℃.Formula of 1-Phenylbuta-2,3-dien-1-one Avoid repeated freeze / thaw cycles.PMID:33608921
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 131 kDa
Positive control :
RAW264.7 treated with 1μg/mL LPS for 24 hours whole cell lysate.