Armacol Sci 23(9):434?40. 14. Brandsch M (2009) Transport of drugs by proton-coupled peptide transporters: Pearls and pitfalls. Expert Opin Drug Metab Toxicol five(eight):887?05. 15. Paulsen IT, Skurray RA (1994) The POT family members of transport proteins. Trends Biochem Sci 19(10):404. 16. Hauser M, Kauffman S, Naider F, Becker JM (2005) Substrate preference is altered by mutations within the fifth transmembrane domain of Ptr2p, the di/tri-peptide transporter of Saccharomyces cerevisiae. Mol Membr Biol 22(three):215?27. 17. Yeung AK, et al. (1998) Molecular identification of a role for tyrosine 167 inside the function from the human intestinal proton-coupled dipeptide transporter (hPepT1). Biochem Biophys Res Commun 250(1):103?07. 18. Hagting A, vd Velde J, Poolman B, Konings WN (1997) Membrane topology of your diand tripeptide transport protein of Lactococcus lactis. Biochemistry 36(22):6777?785. 19. Covitz K-MY, Amidon GL, Sad W (1998) Membrane topology from the human dipeptide transporter, hPEPT1, determined by epitope insertions. Biochemistry 37(43): 15214?5221. 20. Solcan N, et al. (2012) Alternating access mechanism within the POT household of oligopeptide transporters. EMBO J 31(16):3411?421. 21. Doki S, et al. (2013) Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT. Proc Natl Acad Sci USA 110(28):11343?1348. 22. Guettou F, et al. (2013) Structural insights into substrate recognition in protondependent oligopeptide transporters. EMBO Rep 14(9):804?10. 23. Malle E, et al. (2011) Random mutagenesis with the prokaryotic peptide transporter YdgR identifies possible periplasmic gating residues. J Biol Chem 286(26):23121?3131. 24. Jensen JM, et al. (2012) Functional investigation of conserved membrane-embedded glutamate residues inside the proton-coupled peptide transporter YjdL. Protein Pept Lett 19(three):282?87. 25. Jensen JM, Ismat F, Szakonyi G, Rahman M, Mirza O (2012) Probing the putative active web-site of YjdL: An uncommon proton-coupled oligopeptide transporter from E. coli. PLoS A single 7(10):e47780. 26. Jensen JM, et al. (2012) Biophysical characterization from the proton-coupled oligopeptide transporter YjdL. Peptides 38(1):89?3. 27. Casagrande F, et al. (2009) Projection structure of DtpD (YbgH), a prokaryotic member from the peptide transporter family. J Mol Biol 394(4):708?17. 28. Kedrov A, Janovjak H, Sapra KT, M ler DJ (2007) Deciphering molecular interactions of native membrane proteins by single-molecule force spectroscopy. Annu Rev Biophys Biomol Struct 36(1):233?60. 29. Engel A, Gaub HE (2008) Structure and mechanics of membrane proteins. Annu Rev Biochem 77(1):127?48. 30. Kedrov A, Krieg M, Ziegler C, Kuhlbrandt W, Muller DJ (2005) Locating ligand binding and activation of a single antiporter.1073371-77-3 Chemical name EMBO Rep 6(7):668?74.2-Bromo-4-formylnicotinonitrile site 31.PMID:33412965 Kedrov A, Ziegler C, Muller DJ (2006) Differentiating ligand and inhibitor interactions of a single antiporter. J Mol Biol 362(five):925?32. 32. Kedrov A, et al. (2010) Probing the interactions of carboxy-atractyloside and atractyloside with the yeast mitochondrial ADP/ATP carrier. Structure 18(1):39?6. 33. Ge L, Perez C, Waclawska I, Ziegler C, Muller DJ (2011) Locating an extracellular K+dependent interaction web-site that modulates betaine-binding from the Na+-coupled betaine symporter BetP. Proc Natl Acad Sci USA 108(43):E890 898. 34. Zocher M, Fung JJ, Kobilka BK, M ler DJ (2012) Ligand-specific interactions modulate kinetic, energetic, and mechanical properties on the human two adrenergic receptor. Structure 20(eight.