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THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 19, pp. 13269 ?3277, Might 10, 2013 ?2013 by The American Society for Biochemistry and Molecular Biology, Inc.3-Penten-2-one uses Published inside the U.2-Hydrazinylthiazole hydrochloride web S.PMID:33475021 A.The Arf/p53 Protein Module, Which Induces Apoptosis, Down-regulates Histone H2AX to Allow Standard Cells to Survive in the Presence of Anti-cancer Drugs*SReceived for publication, July 18, 2012, and in revised type, March 25, 2013 Published, JBC Papers in Press, March 27, 2013, DOI ten.1074/jbc.M112.Yuko Atsumi?, Aki Inase?, Tomoyuki Osawa 1, Eiji Sugihara**, Ryo Sakasai, Hiroaki Fujimori, Hirobumi Teraoka, Hideyuki Saya**, Masamoto Kanno��, Fumio Tashiro , Hitoshi Nakagama? Mitsuko Masutani, and Ken-ichi Yoshioka2 From the Division of Genome Stability Study and ivision of Cancer Improvement Method, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan, the �Department of Biosciences, College of Science, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara 228-8555, Japan, Biological Science and Technology, Tokyo University of Science, 6-1-1 Niijuku, Katsushi.