Product Name :
(2R,4R)-APDC (CAS 169209-63-6)
Synonym :
Application :
(2R,4R)-APDC is a highly selective agonist for group II metabotropic glutamate receptors (mGluR)
CAS:
169209-63-6
Purity:
>98%
Molecular Weight:
174.16
Formula :
C6H10N2O4
Physical state:
Solid
solubility :
Soluble in water.
Shipping Condition :
Store at room temperature
Melting point:
292.77° C (Predicted)
SMILES:
C1[C@@H](NC[C@]1(C(=O)O)N)C(=O)O
References:
:Effect of the group II metabotropic glutamate agonist, 2R,4R-APDC, varies with age, layer, and visual experience in the visual cortex.Azido-PEG9-amine supplier | Beaver, CJ., et al. 1999. J Neurophysiol. 82: 86-93. PMID: 10400937Pharmacological agents acting at subtypes of metabotropic glutamate receptors.2-Amino-4-bromo-3-fluorobenzoic acid Order | Schoepp, DD.PMID:33591456 , et al. 1999. Neuropharmacology. 38: 1431-76. PMID: 10530808The mGlu(2/3) agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate, is anti- and proconvulsant in DBA/2 mice. | Moldrich, RX., et al. 2001. Neurosci Lett. 299: 125-9. PMID: 111669542R,4R-APDC influence on hypoxia-induced impairment of learning and memory processes in passive avoidance test. | Car, H., et al. 2004. Pol J Pharmacol. 56: 527-37. PMID: 155916402R, 4R-APDC decreases cell proliferation in the dentate gyrus of adult rats: the effect of 2R, 4R-APDC on cell proliferation. | Yao, H., et al. 2007. Neuroreport. 18: 1459-62. PMID: 17712274Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. | Gross, O., et al. 2009. Nature. 459: 433-6. PMID: 19339971Effects of the group II mGlu receptor agonist 2R,4R-APDC on dentate gyrus cell proliferation in the adult rat brain after diffuse brain injury. | Feng, YB., et al. 2011. Neurol Res. 33: 381-8. PMID: 21535937Inhibitory effect of group II mGluR agonist 2R, 4R-APDC on cell proliferation in dentate gyrus in rats with epileptic seizure. | Yao, H., et al. 2015. Eur Rev Med Pharmacol Sci. 19: 2922-7. PMID: 26241549Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4- dicarboxylate. | Schoepp, DD., et al. 1995. Neuropharmacology. 34: 843-50. PMID: 8532165Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. | Monn, JA., et al. 1996. J Med Chem. 39: 2990-3000. PMID: 8709133Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I- and II- selective metabotropic glutamate receptor agonists. | Mistry, R., et al. 1998. Br J Pharmacol. 123: 581-9. PMID: 9504400Specific group II metabotropic glutamate receptor activation inhibits the development of kindled epilepsy in rats. | Attwell, PJ., et al. 1998. Brain Res. 787: 286-91. PMID: 9518652Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death. | Battaglia, G., et al. 1998. Eur J Pharmacol. 356: 271-4. PMID: 9774259